Great post! Would love to see something similar on another repurposing story - neurokinin-3 receptor antagonists going from failed schizophrenia drug to successful menopausal treatment
Incidentally (re: footnote), sildenafil (and presumably other PDE5 inhibitors) has shown promise in treating moderate to severe menstrual cramping when administered as a vaginal suppository. I wouldn’t be surprised if drug repurposing could be used as as an avenue for treatment of lots of different underserved conditions (similarly, there’s lots of folk evidence for the use of pepcid’s active ingredient in treating PMDD).
Great post! Would love to see something similar on another repurposing story - neurokinin-3 receptor antagonists going from failed schizophrenia drug to successful menopausal treatment
https://open.substack.com/pub/rationalpsychiatry/p/repurposing-a-failed-class-of-schizophrenia?r=g83wq&utm_medium=ios
Incidentally (re: footnote), sildenafil (and presumably other PDE5 inhibitors) has shown promise in treating moderate to severe menstrual cramping when administered as a vaginal suppository. I wouldn’t be surprised if drug repurposing could be used as as an avenue for treatment of lots of different underserved conditions (similarly, there’s lots of folk evidence for the use of pepcid’s active ingredient in treating PMDD).