The difference between a drug’s “therapeutic effect” and “side effects” is, of course, a matter of perspective. Sildenafil was a drug for hypertension before it was repurposed as a treatment for erectile dysfunction, medicalizing the condition in the process (an earlier attempt, involving
>If you’re a scientist, meanwhile, you can also use tetracycline to control transcriptional activation (the Tet-On or Tet-Off systems) or check if wildlife are consuming a certain bait by dosing their bait with tetracycline and then checking their teeth.
I, and most other researchers, use doxycycline for this instead of tetracycline, since doxycycline is more stable. But it still has off-target effects on mitochondria especially at high concentrations. It also inhibits certain matrix metalloproteases.
>If you’re a scientist, meanwhile, you can also use tetracycline to control transcriptional activation (the Tet-On or Tet-Off systems) or check if wildlife are consuming a certain bait by dosing their bait with tetracycline and then checking their teeth.
I, and most other researchers, use doxycycline for this instead of tetracycline, since doxycycline is more stable. But it still has off-target effects on mitochondria especially at high concentrations. It also inhibits certain matrix metalloproteases.