Amazing work. I used to work on the fringes of rational drug design in its early years and thoroughly believe a return to irrational, phenotype effect testing like happened in the early days of organic chemistry and pharmacology would yield more meaningful results (though less clever papers "explaining" what is going on). Can drugs still be approved today where the molecular mechanism of action is unknown?
How did you find out that memantine definitely doesn't work? The wikipedia article and everything that came up on a quick google search claims some efficacy, including a few scientific articles published years after its approval in 2003.
Wait a minute. Preventing the production of mutant SOD1 doesn't restore wild-type SOD1, perhaps that's what's actually important?
edit: there is some evidence against my idea: https://www.nature.com/articles/s41598-020-77716-5
Amazing work. I used to work on the fringes of rational drug design in its early years and thoroughly believe a return to irrational, phenotype effect testing like happened in the early days of organic chemistry and pharmacology would yield more meaningful results (though less clever papers "explaining" what is going on). Can drugs still be approved today where the molecular mechanism of action is unknown?
Excellent piece. Thank you.
Great article, very insightful read.
How did you find out that memantine definitely doesn't work? The wikipedia article and everything that came up on a quick google search claims some efficacy, including a few scientific articles published years after its approval in 2003.